Byonic™ is our full MS/MS search engine providing unequaled sensitivity for comprehensive peptide and protein identification. As a node in Byos®, Byonic™ results are incorporated automatically along with the raw mass spec data and any HPLC data.
Byonic provides several major features not found in the other search engines:
MODIFICATION FINE CONTROL
This fine-tuned modification control enables Byonic to streamline its search, targeting candidate peptides most apt to align with mass spectra
WILDCARD SEARCH
Enables the user to search for unanticipated, or even unknown, modifications
GLYCOPEPTIDE SEARCH
Enables the user to search for glycosylated peptides, without prior knowledge of either glycosylation sites or glycan masses
TOP-DOWN, MIDDLE-DOWN, AND BOTTOM-UP PROTEOMICS
Byonic is uniquely capable of top-down, middle-down, and bottom-up searches, but it relies upon isotope-resolved precursors in order to determine precursor ion charges
DISULFIDE BONDS, TRISULFIDE BONDS, AND GENERAL CROSSLINKING
Byonic has disulfide bond, trisulfide bond, and general crosslink search capability. It is designed to search for all disulfide pairs (both expected and shuffled disulfide bonds) and the user can constrain which protein chains to consider when doing the search